2020
Yes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501199/#:~:text=Obesity%20May%20Enhance%20the%20Adverse%20Effects%20of%20NO2%20Exposure,on%20Asthma%20Symptoms%20in%20Children
Permaul, Perdita
North America
Observational
Epidemiology Study
Students
Elementary (K-5)
Nitrogen Dioxide (NO2)
Absenteeism
Respiratory symptoms
Asthma
Obesity
Body mass index (BMI)
Inner-city
Urban
School
Nitrogen dioxide (NO2)
Nitrogen dioxide (NO2)
Children
Environment
Exposure
Indoor
Pollutants
Air
A total of 271 predominantly black (35%) or Hispanic students (35%) were included in analyses. Fifty percent were normal weight (5-84th BMI percentile), 15% overweight (≥85-94th BMI percentile), and 35% obese (≥95th BMI percentile). For each 10-parts per billion increase in NO2, obese students had a significant increase in the odds of having an asthma symptom day (odds ratio [OR], 1.86; 95% CI, 1.15-3.02) and in days caregiver changed plans (OR, 4.24; 95% CI, 2.33-7.70), which was significantly different than normal weight students who exhibited no relationship between NO2 exposure and symptom days (OR, 0.90; 95% CI, 0.57-1.42; pairwise interaction P = .03) and change in caregiver plans (OR, 1.37; 95% CI, 0.67-2.82; pairwise interaction P = .02). Relationships between NO2 levels and lung function and fractional exhaled nitric oxide did not differ by BMI category. If we applied a conservative Holm-Bonferroni correction for 16 comparisons (obese vs normal weight and overweight vs normal weight for 8 outcomes), these findings would not meet statistical significance (all P > .003).